Pigmentation disorders are more than visible signs of aging; they also reflect an invisible process — the accumulation of oxidative stress within skin cells, a key driver of skin aging. This biological process is universal, affecting all skin types regardless of tone or phototype.

To counter mechanism, Codif’s new active ingredient targets lipofuscin, a pro-oxidant pigment deeply involved in the cellular aging process.

With age, cellular autophagy gradually slow down. This natural process becomes less efficient, damaged cellular structures and molecules are not fully recycled allowing lipofuscin to accumulate. Because of its pro-oxidant nature, lipofuscin then becomes a source of imbalance itself, generating reactive oxygen species (ROS) and recreating local oxidative stress. “These ROS also activate melanogenesis stimulating melanin production, which leads to visible spots. Gradually, lipofuscin and melanin aggregate, forming pigment clusters that become increasingly difficult to degrade,” explains Codif.

Lactopalm Para breaks this vicious cycle through dual action, reducing lipofuscin formation upstream (-32%) and limiting both its accumulation and pro-oxidant activity downstream (-62%).

“Today, taking care of your skin is no longer just about correcting visible signs of aging. Skin longevity has now naturally become part of the cosmetic approach, aiming to support, day after day, the biological mechanisms of our skin to preserve its balance and slow down aging processes,” emphasizes Codif.

Tested on 30 different carnations

The efficacy of Lactopalm Para at a 1% concentration has been validated by an in vivo test on 105 women with over 30 different skin tones.

The effect on complexion and dark spots is visible after just 14 days: spots decrease by -14%, skin texture is smoother (+29%), and radiance improves (+52%). [1]

In the longer term, Codif notes a significant improvement in skin tone evenness compared to placebo, and a significant reduction in the number of dark spots compared to placebo.

At the end of the treatment, 81% of users reported visibly younger-looking skin.

In vitro tests demonstrate Lactopalm Para’s ability to reduce protein oxidation and stimulate autophagy to better eliminate damaged proteins. It thus prevents the accumulation of lipofuscin and eliminates age spots. The active ingredient also regulates melanogenesis genes and reduces melanin accumulation.

Red algae

Lactopalm Para is derived from Palmaria palmata, a red algae species belonging to the Florideophyceae class, through a lacto-fermentation process using Lactobacillus plantarum, a bacterium isolated from one of Codif’s signature plants.

According to the supplier, this fermentation process releases floroside — the key active molecule in Lactopalm Para — while also generating vitamins, fermentation metabolites, and lactic acid. Together, these compounds enhance floroside’s ability to help modulate oxidative stress.