Metallomia, the latest detoxifying active ingredient from French manufacturer Silab, was specifically developed to target the deficiency of ferritinophagy in menopausal skin.
“Metallo-aging”
Actually, thanks to a novel modeling study on menopausal skin, Silab has shown a deficiency of this key that ensures the controlled release of iron to meet the needs of cells.
The deficiency of ferritinophagy observed during menopause induces a lack of bioavailable iron, which leads to premature aging of the skin. This phenomenon of metallo-aging is augmented by UV radiation. Indeed, the latter favors the degradation of iron/ferritin complexes, thereby leading to the massive and uncontrolled release of iron and causing significant oxidative stress.
Silab’s new active ingredient prevents these problems by relaunching ferritinophagy in menopausal skin. Metallomia facilitates the provision of iron and relaunches the main epidermal functions. In addition, by reducing the iron/ferritin complexes, the active ingredient limits oxidative stress in case of exposure to UV.
Detoxifying action
According to Silab, thanks to this targeted mechanism, metallo-aging is significantly reduced. As of 14 days, the skin of Caucasian volunteers is revitalized: the skin barrier is reinforced, and the complexion is unified and radiant. Pigment spots are also significantly reduced in Asian volunteers after 28 days.
In addition, applied by Caucasian volunteers prior to exposure to UV, the active ingredient prevents lipid peroxidation. Within hours after exposure to UV, the appearance of redness is limited.
Traced and secured supply chain
For the development of Metallomia, Silab got interested in the molecular composition of marshmallow roots, particularly rich in mucilages, and has implemented a traced supply chain with French partners. This supply has been validated with the criteria described in the European Pharmacopoeia and by authentication by DNA barcoding. In order to benefit from the richness in mucilages of marshmallow roots, a specific enzyme engineering process was developed to extract polyuronides.
Metallomia is a patented active ingredient recommended in all care products intended for menopausal skin at a dose of 0.5 à 2%. Available in aqueous solution, it is easy to formulate. It complies with biodiversity regulations and has a natural origin content of 100% (ISO 16128). It complies with international cosmetics regulations (Europe, USA, China, Japan, etc.).
