For this new patented natural active ingredient, dedicated to the vitality of deficient skin, Silab took advantage of the adaptation capabilities of a bacteria living in symbiosis with ginseng.
Indeed, Ginseng is known to cause numerous changes and deficiencies in its environment, impacting the availability of nutrients, especially nitrogen. To survive in this hostile environment, the Sphingomonas panaciterrae bacterium, present in the ginseng rhizosphere, deploys protective mechanisms via the production of sphingane-type Exopolysaccharides (EPS). It exhibits for itself and its host bio-protective and bio-stimulant properties, granting it an incredible "vitality capital." These are the characteristics that Silab has chosen to enhance in its new active ingredient, Revilience.
Bioguiding and enzymatic engineering
The French company has developed a biotechnological process of controlled nitrogen deficiency applied to Sphingomonas panaciterrae, which doubled its EPS production compared with a non-deficient process. “Coupled with a specific enzymatic hydrolysis, this unique bio-inspired approach resulted in an active ingredient composed of oligosphinganes of interest, capable of improving the metabolism of skin lacking vitality,” said Silab in a statement.
To highlight the pathways of action, Silab relied on transcriptomics and, thanks to an unprecedented modelling study, the manufacturer has established the gene mapping of skins subjected to nutritional deficiency (growth factor depletion) or physiological deficiency (aging). These two deficiency conditions revealed a common degradation of epidermal cell metabolism and protection mechanisms.
According to Silab, by reactivating these biological pathways in deficient skin, Revilience restores the skin’s "vitality signature". Cellular metabolism is thus stimulated, and the quality of the cutaneous barrier reinforced. Tested at 2.5% on young and mature Caucasian volunteers, the active ingredient enhances complexion radiance and improves hydration as early as seven days after treatment.
Silab recommends Revilience in all skincare products for skin lacking vitality at a dose of 0.5 to 2.5%. Available in an aqueous solution, it has a natural origin content of 98.8% (ISO 16128).