Senescence [1] is usually controlled by the immune system, that effectively locates and eradicates cells that are harmful to the cutaneous environment. Over time, however, some senescent fibroblasts implement immunoevasion strategies to avoid being eliminated. That precisely the immunoevasion mechanism that is targeted by Silab’s new anti-ageing active ingredient.

A new mechanism of action

Thanks to in vitro and in vivo modelling studies, Silab says they have shown the accentuation of the immunoevasion mechanism at the level of the skin after the age of 60, inducing profound changes (wrinkles, dull complexion, loss of elasticity and senescence spots).

“Through its targeted action, Senevisium is able to restore the natural elimination of immunoevasive senescent fibroblasts by the immune system by circumventing their two immunoevasion pathways,” claims the company.

In-vivo tested efficacy

According to Silab, by allowing deleterious immunoevasive senescent fibroblasts to be recognized again and eliminated, Senevisium protects the skin from their harmful effects on matrix synthesis and epidermal renewal.

“Tested at 2% in Caucasian volunteers, Senevisium enables the skin to restore its density and elasticity. The stage of wrinkles is reduced, and complexion radiance is enhanced,” details the company.

After 28 days of treatment, 100% of the female volunteers said they found their skin firmer, and their complexion lighter and more uniform.

Extracted from Ginkgo Biloba leaves grown in France

Silab extracted Senevisum’s active molecules from leaves of Ginkgo Biloba, a tree known for its powerful immune system. Two French farms, certified for their organic and biodiversity-friendly processes, were selected for the supply of the green leaves.

The company recommends to use Senevisium in skin care products dedicated to mature skins at a concentration of 0.5 to 2.0%. Available in aqueous solution, it complies with biodiversity regulations and has a natural origin content of 98.8% (ISO 16128). It meets international cosmetic regulations requirements (Europe, United States, China, Japan, etc.).