In an era where sustainability and traceability are top of mind for consumers, the sourcing story of Mangixyl™ highlights our commitment to our Company Purpose. The mango leaves are collected in collaboration with the Association Bendia, based in Koro village (Burkina Faso, Africa). The association is a women-led initiative to contribute to the improvement of the living conditions of the community. Derived from the green fractionation of mango leaves, Mangixyl™ is a cosmetic innovation able to activate specific receptors of gene’s pathway normally regulated by the highly potent retinoic acid.
Mangixyl™, the ethical way to tackle oily skin issues
To fight against the visible appearance of oily skin, applying mattifying powders in order to absorb sebum is a solution; but it requires many applications during the day, and the amount of product to apply is often visible on the face. If sometimes the sebum can be perceived as an enemy for the skin appearance, it’s important to keep in mind that its balance is essential. Indeed, the sebum is an essential part of skin health, since it participates to the hydration of the epidermis and contributes to the suppleness and softness of the epidermis.
By crafting Mangixyl™, Givaudan Active Beauty aims to relieve consumers from the discomfort caused by oily skin. The ingredient activates some receptors of the retinoic acid-regulated genes pathway and decreases the synthesis of lipids on all skin ethnicities.
Sebum reduction for all complexions
Reflecting the company commitment to inclusive beauty, Mangixyl™ is a genderless, universal ingredient that is suitable for all age groups and skin tones. To evaluate the benefits of the ingredient, three clinical tests were conducted in double blind versus placebo, on volunteers from different skin complexions: African (South Africa), Asian (China) and Caucasian (Europe). The measurement of sebum quantity was done on cheeks and nose area at D0 and D28 by sebumeter or sebufix. The tested product was a cream, applied twice a day on the face, containing 1% Mangixyl™ for Caucasian volunteers and 2% of active for Asian and African volunteers. It appears that Mangixyl™ significantly reduces, globally twice better than placebo, the quantity of sebum in only in a month for all skin complexions.
This fully natural and microbiome-friendly active ingredient regulates sebum production (down to 15.9% after one month depending on complexion) to relieve the discomfort caused by oily skin – a widespread concern for consumers around the world. Double-blind tests versus placebo studies have also shown a 49.5% improvement in sebum quality.
A microbiome-friendly active ingredient
Prone-to-acne skin is a multifactorial condition, leading to pimples and irritation, and involving an excess of sebum production. This is why Mangixyl™ was also tested on several factors related to acne. During in vitro test, Mangixyl™ showed a 29% inhibitory action on C. acnes lipase activity.
In the double blind versus placebo clinical study performed on European women with oily skin, a significant reduction by x2.4 of porphyrins intensity is observed (versus placebo) for 80% of volunteers, reflecting the change of C.acnes metabolism on the skin of volunteers, after one month with Mangixyl™ at 1%. Relative abundance evolution of different bacterial genera showed that Mangixyl™ at 1% protected the skin microbiota over time, whereas the placebo group showed a skin dysbiosis.
Creating for tomorrow
Mangixyl™ is the perfect all-round ingredient for creating skincare solutions that not only free consumers from oily skin, but also meet the rising demand for sustainable, traceable and inclusive products.
Did you know? 
71% of consumers say that oily skin in a source of discomfort
63% say that treating oily skin is difficult
89% would be interested in a natural product that helps balance sebum production
To inspire the beauty industry, Mangixyl™ was featured in a new marketing concept called S3D® Womango. Thanks to its three levels of action, this lightweight, mattifying day cream immediately reduces shine, balances sebum production all day long and reduces excess sebum over time – offering consumers a helping hand in their journey towards a clearer complexion.