The gene, IRF4, was known to affect skin and hair colour through melanin production, but a new study is the first to pinpoint its unique role in the inexorable transition to shades of grey. Further research on precisely how IRF4 works could unlock techniques and treatments that slow or even halt that process, said the scientists.
“An initial avenue has to do with the role IRF4 could play in survival and maintenance of cells that make pigment,” said Andres Ruiz-Linares, a professor at the University College London Genetics Institute who led the study published in the peer-reviewed journal Nature Communications. Understanding how the gene interacts with other genes controlling hair colour, for example, might yield cosmetic applications that block the fade to grey as hair grows in the follicle, he told AFP.
To undertake the analysis, scientists did a so-called genome-wide association scan (GWAS) of 6,630 volunteers in Brazil, Colombia, Chile, Mexico and Peru, matching similarities in their DNA with physical traits. But rather than selecting subjects that shared a common ancestry - all northern Europeans or Japanese, for example - the researchers deliberately mixed things up. Nearly half the participants were of European background, 40 per cent were Native American, and six per cent were of recent African origin.
Depending on ancestry, people tend to go grey at different stages in their lives, the study found. “The average age of hair greying for Caucasians is in the mid-30s,” Ruiz-Linares told AFP. For East Asians, the loss of colour starts in their late 30s, and for sub-Saharan Africans, in their mid- 40s. Likewise, the greying process is said to be “premature” if it starts before the age of 20 in people of European background, and before 25 and 30 among Asians and Africans, respectively.
Setting aside unresolved ethical issues, one could even “wildly contemplate” the use of gene editing, an ultra-precise cut-and-paste process for altering DNA sequences, he said. But the IRF4 variant that favours grey also produces fair hair, he cautioned, so tinking with the gene could also mean fewer blondes.
The size and original design of the research yielded a trove of new results. Another gene, PRSS53, for example, was found to influence curliness, shedding light on the evolution of hair shape that led to straight hair in East Asia and among Native Americans.
A variant of a third gene, PAX3, was strongly associated with “mono-brow”, the tendency - especially among men - for eyebrows to be joined by a bridge of facial hair.