Most of the botox-like face care products come in the form of a simple anti-aging serum, — a gel to be precise — which is simply applied to the face.

The Ordinary’s "Argireline Solution 10%" — which sells for less than $10 — has long been promoted on social networks for its ability to smooth out wrinkles almost as botox would do.

Its main active ingredient, Argireline, a proprietary peptide complex (a solution of Acetyl Hexapeptide-3) from Lipotec (Lubrizol Life Science). The Ordinary says that “studies have shown that Argireline improves the appearance of facial areas prone to developing dynamic folds, including around the eyes and in the forehead area.

But it is now the "Supreme Skin Gel" from the German brand Biotulin that is in the spotlight and makes much ado on social networks. Its main component, spilanthol, is a fatty acid amide extracted from Acmella Oleracea, a plant native to South America — hence it being dubbed ’natural’ botox. This local anesthetic is said to relax the muscles around the eyes and lips, reducing wrinkles in just one hour.

This natural ingredient, which gained popularity in 2021 thanks to German-based organic skincare brand Spilanthox Therapy can b in se foundeveral products such as Patyka’s Age Specific Intensive Instant Wrinkle Filler, or L’Occitane en Provence’s Immortelle Reset Overnight Reset Oil-In-Serum. According to INCI Beauty website, it is present in 0.09% of cosmetic products.

To stand out, Biotulin’s flagship product had the support of Jennifer Lopez who officially thanked the brand on Twitter earlier this year after the Golden Globes awards ceremony.