During the ageing process, the inter cell communication, which is regulated by growth factors, decreases. The activity of fibroblasts is reduced, thus affecting the functions of the extracellular matrix. Consequences to the skin are a loss of firmness, density and elasticity.
Rather than acting on fibroblasts, that hardly reachable with topical products, Mibelle’s DermCom aims to restore inter cellular communication by targeting keratinocytes first. This crocus chrysanthus bulb extract stimulates the growth factors produced by epidermal cells for action on dermal cells.
Genomic measurements show that DermCom increases the expression of CTGF, FGF-5, FGF-7 and ILGFBP6 (growth factors of the epidermis) and mimics the activity of TGF beta (a growth factor of the dermis). Results demonstrate that, after a two-week treatment, dermal synthesis of collagen was improved by +115% and the production of elastin was improved by 25%.
This active, which was launched at the last edition of the In-Cosmetics show, was awarded the silver medal at the Best Ingredient Award.